While much research has focused on the buildup of amyloid plaques in Alzheimer’s disease, a new study conducted by researchers from Yale School of Medicine and Johns Hopkins University targets the harmful changes in tau proteins.
These changes, particularly the phosphorylation of tau, are known to damage neurons and contribute to the progression of the disease.
Understanding the Role of Tau Protein in Alzheimer’s
Tau protein changes, including phosphorylation, lead to the formation of tangles in the brain and subsequent neuronal degeneration. The study focuses on reducing these changes early in the disease’s progression.
The researchers investigate the role of a brain enzyme called GCPll, involved in inflammation, which erodes the protective effects provided by the mGluR3 receptor on neurons. mGluR3 is responsible for facilitating higher cognitive functions.
The study reveals that an inhibitor of GCPll, called 2-MPPA and synthesized by the Johns Hopkins Drug Discovery program, effectively reduces tau phosphorylation.
This promising result was observed in older monkeys with naturally occurring tau pathology.
The next step is to develop a compound that can be used in humans.
The researchers aim to create a GCPll inhibitor that can be taken orally and is safe for human use, emphasizing the potential of this mechanism as a promising avenue for Alzheimer’s disease treatment.
A Promising Path Forward in Alzheimer’s Disease Research
This study offers hope for addressing the damaging changes in tau proteins associated with Alzheimer’s disease.
By focusing on reducing tau phosphorylation early in the disease’s progression, researchers have identified a potential therapeutic target in the form of a GCPll inhibitor.
Developing a safe and effective compound for human use could mark a significant breakthrough in Alzheimer’s disease treatment, potentially offering new avenues for intervention and improved patient outcomes.
The research team remains committed to advancing their work toward this important goal.
If you care about Alzheimer’s, please read studies about Scientists find the root cause of Alzheimer’s disease and findings of Alzheimer’s might not be primarily a brain disease. A new theory suggests it’s an autoimmune condition.
For more information about Alzheimer’s disease, please see recent studies about Foods that reduce Alzheimer’s risk and results showing that Scientists link dietary antioxidants to Alzheimer’s prevention.
The research findings can be found in Alzheimer’s & Dementia: Translational Research & Clinical Interventions.
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