In a new study, researchers found that the risk of greater COVID-19 severity and death is higher in people with any obese body mass index (BMI).
The team that BMI over 30 was associated with a significantly higher risk of respiratory failure, admission to intensive care, and death in COVID-19 patients, regardless of age, gender and other associated diseases.
The current guidelines for identifying those at higher risk in the UK are set at a BMI of 40 but these data suggest people with BMI over 30 should also be classified as at risk.
The research was conducted by a team at the Alma Mater Studiorum University of Bologna in Italy.
Obesity is a growing, global epidemic linked to numerous diseases and an increased risk of death.
Since the onset of the COVID-19 pandemic, several studies have implicated obesity as a risk factor for more severe effects and death in Sars-COV-2 infection.
The UK and USA guidelines for identifying those at greater risk are set at a BMI of 40 and above.
However, these recommendations were necessarily based on smaller studies and limited data, given the novelty and fast progression of the Sars-COV-2 pandemic.
In the study, the team analyzed the outcomes of almost 500 patients hospitalized with COVID-19.
Again, they found that obesity was associated with a significantly higher risk of severity and death but also that any BMI higher than 30 was associated with these adverse outcomes.
The study showed that any grade of obesity is linked to severe COVID-19 illness and suggests that people with mild obesity should also be identified as a population at risk.
The association between higher BMI and severe COVID-19 illness is strong but the cause remains to be explained.
An impaired immunological response to viral infections, alterations of lung function, and obesity-related chronic inflammatory states have all been suggested as the link.
The next step for this research would be to understand these mechanisms.
The team recommends that people and health-care practitioners should be aware of the increased risk of COVID-19 illness with any grade of obesity.
One author of the study is Dr. Matteo Rottoli.
The study is published in the European Journal of Endocrinology.
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