A groundbreaking study from Johns Hopkins Medicine has revealed that a drug originally developed for brain conditions such as Alzheimer’s disease and schizophrenia may also be effective in treating obesity.
Even more surprising, this treatment could work without requiring people to change their diet or exercise habits.
The drug targets an enzyme called PDE9, which is involved in several conditions, including sickle cell disease and high blood pressure-related heart disease.
Scientists found that blocking this enzyme could help reduce body weight and also improve health markers like blood pressure, blood sugar, cholesterol, and body fat around the waist—all of which are often problems for people with obesity.
The drug, known as PF-04447943, was first developed and tested by Pfizer Inc. in clinical trials for Alzheimer’s disease. Over 100 people took the drug during those trials, and it was shown to be safe with no serious side effects. However, it was eventually shelved for its original purpose.
In the recent study, researchers tested the drug on mice. The results were remarkable: mice given the drug lost a significant amount of weight without any changes to their food intake or physical activity. This points to the drug’s powerful potential in managing obesity. If these results can be replicated in humans, it could lead to a revolutionary new treatment.
To put it into perspective, a person who weighs 250 pounds might lose about 50 pounds by simply taking this medication—without needing to change what they eat or how much they exercise.
Obesity is a growing health issue around the world, and especially in the United States. The Centers for Disease Control and Prevention (CDC) reports that over 40% of American adults are obese.
The rate is even higher among women over 60, with 43% falling into this category. Obesity is linked to a wide range of serious health problems, including diabetes, heart disease, and certain cancers.
If this drug proves effective and safe in human trials, it could become a life-changing option for millions of people. Many who struggle to lose weight due to physical, emotional, or medical barriers may finally have access to an easier and more sustainable solution.
This research is a perfect example of how medical science can take unexpected paths. A treatment originally designed for brain disorders may end up addressing one of today’s most widespread health challenges. It also highlights the importance of continued research and innovation in the field of medicine.
The team at Johns Hopkins is hopeful and plans to conduct more studies to test the drug in human patients. If successful, it could usher in a new era in obesity treatment, helping people lead healthier, longer lives without the pressure of major lifestyle changes.
If you care about brain health, please read studies about Scientists find connection between fungus and Alzheimer’s disease and findings of Scientists find links between COVID-19 and Alzheimer’s disease.
For more about Alzheimer’s disease, please read studies about Research shows root cause of Alzheimer’s disease and new treatment and findings of Scientists find the link between eye disease glaucoma and Alzheimer’s disease.
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