Non-invasive blood test can predict Alzheimer’s disease 20 years before symptoms occur

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Researchers from The Australian National University (ANU) have made substantial progress in the early detection of Alzheimer’s, developing a simple, affordable, and non-invasive blood test that could predict the risk of Alzheimer’s up to 20 years prior to symptom onset.

Using a combination of nanotechnology and artificial intelligence (AI), the physicists have created a technique to analyze proteins in the blood, identifying early biomarkers for Alzheimer’s disease.

Methodology and Technology

The scientists have engineered an ultra-thin silicon chip embedded with nanopores—minute holes in the nanometer range.

When a small amount of blood is placed on this chip, these nanopores, with the aid of an advanced AI algorithm, analyze individual proteins to detect early signs of neurodegeneration linked to Alzheimer’s.

The blood test is performed using a portable device, approximately the size of a mobile phone.

Potential Impact

This innovative method provides significant advancements over current Alzheimer’s detection methods, which usually rely on evidence of mental deterioration and involve invasive and costly procedures.

The technology developed by ANU can deliver near real-time results based on just a small blood sample, enabling early and easier detection, potentially even by general practitioners, thus eliminating the need for hospital visits.

This proves particularly beneficial for individuals residing in remote and regional locations.

Broader Applications

Beyond Alzheimer’s, the developed algorithm has the capacity to be trained for the screening of various neurological conditions simultaneously, including Parkinson’s disease, multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS).

Significance of Early Detection

While there’s currently no cure for Alzheimer’s, early detection of the disease could offer patients the opportunity to make lifestyle adjustments and undertake medication strategies to potentially slow the progression of the disease, enhancing health outcomes significantly.

Shankar Dutt, an ANU Ph.D. researcher, emphasizes the importance of people knowing their risk level well in advance, allowing ample time for preventive measures and interventions.

Societal Context

Alzheimer’s, the most prevalent form of dementia, is a major health concern, especially in Australia, where it is the second leading cause of death.

The number of Australians living with dementia is expected to exceed 400,000, potentially doubling by 2058.

Early detection is particularly critical for high-risk populations, such as Aboriginal and Torres Strait Islander people, who face a three to five times higher risk of developing dementia compared to the general Australian population.

Challenges and Future Direction

Identifying proteins indicative of early neurodegeneration is likened to searching for a needle in a haystack due to the complexity of blood, which contains over 10,000 different biomolecules.

However, the integration of advanced filtration techniques, nanopore platform, and intelligent machine learning algorithms can potentially pinpoint even the most elusive proteins.

The scientists at ANU are hopeful that this groundbreaking screening technique could be available to the public within the next five years, representing a monumental step in Alzheimer’s research and early detection.


The development of a non-invasive, affordable, and simple blood test for the early detection of Alzheimer’s by the physicists at The Australian National University is a significant breakthrough in the field.

This method, combining nanotechnology and artificial intelligence, enables the analysis of blood proteins to identify early signs of Alzheimer’s, providing an opportunity for preventive strategies and improved health outcomes for at-risk individuals.

The potential broader application of this technology for detecting other neurological conditions makes it a powerful tool in the advancement of neurological research and healthcare.

If you care about dementia, please read studies about Dietary antioxidants crucial in Alzheimer’s disease prevention and findings of Scientists find the Link between poor sleep, brain inflammation, and Alzheimer’s risk.

For more information about brain health, please see recent studies about 9 unhealthy habits that damage your brain, and results showing this stuff in cannabis may protect aging brain, treat Alzheimer’s.

The research findings can be found in Small Methods.

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