In a recent study, researchers found that the high amounts of dietary sugar in the typical western diet may increase the risk of breast cancer and metastasis to the lungs.
They found dietary sugar’s effect on an enzymatic signaling pathway known as 12-LOX (12-lipoxygenase).
Previous studies have shown that sugar intake has an impact on breast cancer development.
In the study, the team examined how sugars influence mammary gland tumor development in multiple mouse models.
They found that it was specifically fructose, in table sugar and high-fructose corn syrup, ubiquitous within our food system. It was responsible for lung metastasis and 12-HETE production in breast tumors.
The researchers added that dietary sugar induces 12-LOX signaling to increase risks for breast cancer development and metastasis.
Identifying risk factors for breast cancer is a public health priority.
They suggested that moderate sugar intake is critical, given that the per capita consumption of sugar in the U.S. has surged to over 100 lbs. per year.
There is an increase in consumption of sugar-sweetened beverages, which has been identified as a significant contributor to an epidemic of obesity, heart disease and cancer worldwide.
If you care about cancer, please read studies that mammograms over-diagnose 1 in 7 breast cancers in the U.S, and new way to increase the longevity of cancer survivors.
For more information about cancer, please see recent studies about sweeteners linked to increased cancer risk, and results showing new way to supercharge cancer-fighting T cells.
The study was published in Cancer Research.
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