A common consequence of chronically high alcohol consumption is a decline in cognitive function, which can even progress to full-blown dementia.
This is then referred to as alcohol-related dementia.
In a recent study from MedUni Vienna, scientists developed a hypothesis whereby iron deposits in the brain—resulting from alcohol-induced vitamin B1 deficiency—can be regarded as key factors in cognitive decline.
Cognitive deterioration is caused by iron deposits in the brain, but the administration of vitamin B1 could protect the brain from these deposits.
Previous research had shown that iron deposits in the brain are responsible for nerve tissue damage.
These deposits can also be detected in specific regions of the brain (including the basal ganglia) in people who drink a lot of alcohol.
The hypothesis advanced by the study authors now also offers an explanation as to why iron deposits are so prevalent in this patient group:
High alcohol consumption results in elevated iron levels in the blood and vitamin B1 (thiamine) deficiency, which, among other things, is important for maintaining the blood-brain barrier.
If these two situations coincide, more iron will be deposited inside the brain, ultimately leading to oxidative tissue damage.
The role of vitamin B1 in this process could represent a huge step forward in our understanding of the development of alcohol-related neurological damage and, in particular, could offer a new point of attack for preventive and therapeutic approaches.
It would then be conceivable to give continuous vitamin B1 substitution in the future as a preventive measure.
The researchers believe it would also be useful to evaluate the use of drugs to reduce iron levels (e.g. chelators), as is already done in other neurodegenerative diseases.
If you care about nutrition, please read studies about six vitamins that help stop complications in diabetes, and vitamin D may benefit men with advanced cancer.
For more information about dementia, please see recent studies that cataract removal may reduce the dementia risk by 30%, and results showing this metal may reduce the risk of dementia.
The study is published in the leading journal Alzheimer’s and Dementia. One author is Stephan Listabarth.
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