In a new study from Curtin University, researchers discovered a likely cause of Alzheimer’s disease.
They identified that a probable cause of Alzheimer’s disease was the leakage from the blood into the brain of fat-carrying particles transporting toxic proteins.
The researchers say they have identified the probable ‘blood-to-brain pathway’ that can lead to Alzheimer’s disease, the most prevalent form of dementia globally.
This ‘blood-to-brain pathway’ is significant because if doctors can manage the levels in the blood of lipoprotein-amyloid and prevent their leakage into the brain, this opens up potential new treatments to prevent Alzheimer’s disease and slow memory loss.
In the study, the team tested the ground-breaking ‘blood-to-brain pathway’ by genetically engineering mouse models to produce human amyloid-only liver that makes lipoproteins.
They found that mouse models producing lipoprotein-amyloid in the liver suffered inflammation in the brain, accelerated brain cell death and memory loss.
This finding shows the abundance of these toxic protein deposits in the blood could potentially be addressed through a person’s diet and some drugs that could specifically target lipoprotein amyloid, therefore reducing their risk or slowing the progression of Alzheimer’s disease.
The findings may have a significant global impact on the millions of people living with Alzheimer’s disease.
If you care about Alzheimer’s disease, please read studies about these 2 personality traits may protect you from Alzheimer’s disease and more and findings of a new early sign of Alzheimer’s disease.
For more information about Alzheimer’s and your health, please see recent studies about this sleep problem linked to Alzheimer’s disease and results showing that this common type of drug linked to higher risk of Alzheimer’s disease.
The study is published in PLOS Biology. One author of the study is John Mamo.
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