In a new study, researchers found a new drug that holds exciting possibilities for the treatment of cancers and many other diseases.
The research was conducted by a team at Creighton University and UCLA.
The new drug HM-10/10 is developed from proteins used to diagnose ovarian cancer. It has been effective in inhibiting tumor growth in colorectal and ovarian cancers in mice.
HM-10/10 is an artificial peptide that mimics high-density lipoprotein (HDL), the so-called “good cholesterol.”
In the study, a group of lab mice that had consumed a diet that included the HM-10/10 peptide was found to have a much lower tumor load than mice that had not eaten the peptide.
The drug also shows the potential to treat other pro-inflammatory diseases, such as macular degeneration, heart disease, Alzheimer’s and endometriosis.
Prior to publishing on its effectiveness as a cancer treatment, the team published another paper showing HM-10/10’s potential to treat retinal disease (e.g. macular degeneration).
The team previously discovered the depletion of a certain protein, ApoA-1, in ovarian cancer patients created a hospitable environment for cancer to thrive.
With this in mind, the team created HM-10/10 using elements of the ApoA-1 protein alongside other constituent proteins.
The lead author of the study is Robin Farias-Eisner, MD, Ph.D.
The study is published in the Journal of Cancer Research and Therapeutic Oncology.
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