In a new study, researchers found that weight loss in obese patients with obstructive sleep apnea (OSA) appears to improve sleep apnea primarily by reducing tongue fat.
The study is the first to show that weight loss reduces tongue fat in people with OSA.
The research was conducted by a team at the University of Pennsylvania and elsewhere.
Patients with OSA stop breathing repeatedly for short periods during sleep.
Obesity is the primary risk factor for OSA, and previous studies have shown that decreases in body weight result in decreases in the Apnea/Hypopnea Index (AHI), a measure of how often a patient’s breathing stops completely or partially while sleeping.
In a previous study, researchers had shown that tongue fat was increased in obese patients with sleep apnea compared to obese controls without sleep apnea.
In this study, the team used magnetic resonance imaging, or MRI, to measure the effect of weight loss on the pharyngeal structures surrounding the upper airway, which extends from the mouth to the larynx.
The study included 67 participants with mild to severe OSA who were obese. Through diet or weight loss surgery, the patients lost nearly 10% of their body weight on average over six months.
Overall, the participants’ AHI scores improved by 30.7% as measured by polysomnograpy, or sleep study.
The study found that reductions in tongue fat resulted in the greatest improvements in OSA.
About 30% of the improvement was attributable to the changes in tongue fat, and the more weight a patient lost, the more tongue fat was reduced and the greater the improvement in OSA.
The study also found that weight loss resulted in reduced pterygoid (one of the jaw muscles that controls chewing) and pharyngeal lateral wall [muscles on the sides of the airway] volumes.
Both these changes also improved OSA, but not to the same extent as reduced tongue fat. Weight loss was not associated with other upper airway changes.
The authors believe that their findings present a potential new therapeutic target for OSA: tongue fat.
They suggest that future studies could be designed to explore whether certain low-fat diets are better than others in reducing tongue fat and whether cold therapies used to reduce stomach fat might be applied to reducing tongue size.
One author of the study is Richard J. Schwab, M.D.
The study is published in the American Journal of Respiratory and Critical Care Medicine.
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