Diabetes is a health condition that happens when there is too much sugar in the blood.
If this problem continues for a long time, it becomes harder to keep blood sugar levels in a healthy range. One medicine that can help is called semaglutide.
A new study led by Dr. John Buse looked at how different doses of semaglutide affect people’s blood sugar and weight. The study was published in the medical journal The Lancet. It showed that higher doses of the medicine helped people lose more weight and also better control their blood sugar.
In the study, researchers tested three daily doses of semaglutide: 14 milligrams, 25 milligrams, and 50 milligrams. They found that all doses worked to lower blood sugar. But when it came to losing weight, the higher doses gave better results.
People who took 50 milligrams lost an average of 17.5 pounds in one year. Those who took 25 milligrams lost about 14.8 pounds, and the group on 14 milligrams lost around 10 pounds. Dr. Buse explained that while small doses are very good at lowering blood sugar, higher doses can help more with weight loss.
The study included 1,606 people. Most of them were men around the age of 58. At the start, their blood sugar levels were quite high. These were measured using a test called A1C, which tells how well blood sugar has been controlled over the past few months. Healthy A1C levels are below 7%, but the participants had levels between 8.0% and 10.5%.
The people in the study were split into three groups. Each group took one of the three doses of semaglutide every day for a full year. At the end of the study, people taking the 25 mg or 50 mg doses were more likely to have healthy A1C levels under 7%, meaning their blood sugar was better controlled.
Semaglutide also helped people lose weight because it reduced their appetite, so they ate less. But the higher the dose, the more likely people were to have side effects.
The most common side effects were problems with the stomach. These included feeling sick, vomiting, diarrhea, and constipation. These problems happened more often in people who took the 50 mg dose, but most people were able to manage the symptoms.
For people with diabetes, semaglutide could be a strong option for lowering blood sugar and helping with weight loss. The study shows that higher doses like 25 mg and 50 mg are more effective, but they may also come with more side effects.
It’s important for patients to talk with their doctors before starting or changing any dose. The best treatment plan depends on each person’s needs and how they react to the medicine.
This study shows that diabetes care should be personal, aiming to balance how well the medicine works with how it makes the person feel.
Other studies have also shown that sleep problems may be linked to vision loss in people with diabetes, and some drugs could help prevent kidney damage. Healthy foods like blueberries and nutrients like vitamin D may also be helpful.
Making good choices—through medicine, food, and habits—can lead to better health and a better life for people living with diabetes.
If you care about diabetes, please read studies about Vitamin D and type 2 diabetes, and what you need to know about avocado and type 2 diabetes.
For more information about diabetes, please see recent studies about how to eat to prevent type 2 diabetes, and 5 vitamins that may prevent complication in diabetes.
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