Feeling tired is something everyone experiences now and then, but for some aging adults, fatigue becomes a constant and draining part of life.
While fatigue is often linked to common issues like poor sleep, stress, or aging itself, there are some less well-known causes that can also lead to persistent tiredness. Recognizing these rarer causes can make a big difference in finding the right solution and improving quality of life.
One uncommon cause of fatigue is chronic infections. Infections such as Lyme disease, Epstein-Barr virus, or even undiagnosed hepatitis can linger in the body and cause ongoing fatigue. These conditions often go unnoticed because their symptoms can mimic other illnesses or appear mild at first.
For example, Lyme disease, spread by ticks, can cause flu-like symptoms early on but may lead to long-term fatigue and joint pain if left untreated. Research has shown that diagnosing and treating these infections promptly can help relieve fatigue and other symptoms.
Another rare but significant cause of fatigue is adrenal insufficiency, a condition where the adrenal glands do not produce enough hormones like cortisol. Cortisol is critical for managing stress and maintaining energy levels.
When cortisol levels are too low, people may feel extremely tired, weak, or lightheaded, especially during times of stress. Adrenal insufficiency is often linked to autoimmune diseases, such as Addison’s disease, and may require hormone replacement therapy to restore balance.
Some cases of persistent fatigue in aging adults are linked to rare genetic disorders. For instance, mitochondrial diseases, which affect the tiny structures in cells that produce energy, can cause severe tiredness that doesn’t improve with rest.
Although these disorders are uncommon, they can appear later in life and are sometimes misdiagnosed as general aging-related fatigue. Specialized tests and genetic screening can help identify these conditions, which may be managed with tailored treatments and lifestyle changes.
Autoimmune diseases are another rare but important group of conditions to consider. In autoimmune diseases, the body’s immune system mistakenly attacks healthy tissues, causing inflammation and fatigue.
Conditions like lupus, Sjögren’s syndrome, or polymyalgia rheumatica can cause widespread fatigue alongside other symptoms such as joint pain, dry eyes, or muscle stiffness. Many of these diseases are more common in women and older adults, and they often require a combination of medications and lifestyle adjustments to manage.
Sleep disorders are a less obvious but impactful cause of persistent fatigue in aging adults. Rare conditions like narcolepsy or advanced sleep phase syndrome can disrupt normal sleep patterns, leading to excessive tiredness during the day.
These conditions can sometimes be overlooked because they are less well-known, but sleep studies and consultations with sleep specialists can help identify and treat them effectively.
Nutritional deficiencies, particularly rare ones, can also cause ongoing fatigue. While iron deficiency and anemia are commonly known, less common deficiencies like vitamin B12 or folate deficiency can also lead to significant tiredness.
Older adults are more likely to have absorption issues or dietary restrictions that make it harder to get enough of these vital nutrients. Correcting these deficiencies with supplements or dietary changes can lead to dramatic improvements in energy levels.
Finally, certain types of cancer, especially blood cancers like leukemia or lymphoma, can cause chronic fatigue as an early symptom.
Although cancer is a frightening possibility, it’s worth exploring if fatigue is accompanied by unexplained weight loss, fevers, or night sweats. Early detection is key to effective treatment and better outcomes.
Persistent fatigue is often a puzzle with many pieces, and while common causes are the first to check, it’s important not to overlook these rarer possibilities.
If you or someone you know is dealing with long-lasting tiredness, a thorough medical evaluation, including tests for less common conditions, may be necessary. With the right diagnosis and treatment, even rare causes of fatigue can be managed, helping people regain energy and enjoy life again.
If you care about health, please read studies that vitamin D can help reduce inflammation, and vitamin K could lower your heart disease risk by a third.
For more health information, please see recent studies about new way to halt excessive inflammation, and results showing foods that could cause inflammation.
Copyright © 2025 Knowridge Science Report. All rights reserved.