Scientists from the University of Auckland have discovered that a drug called alpelisib, already used for cancer treatment, may also extend the lifespan of mice. The research aimed to explore whether alpelisib could impact aging, in addition to its known cancer-fighting properties.
In the study, the researchers divided healthy mice into two groups. One group received a normal diet, while the other group’s diet included alpelisib. The treatment started when the mice were one year old, considered middle age for mice, and continued for a significant period.
The results were intriguing. Mice on the alpelisib diet lived about 10% longer than those on the control diet, with an average lifespan of around three years. Additionally, these mice showed signs of better health as they aged, including improved coordination and strength.
Despite these positive findings, the researchers remain cautious about applying these results to humans. While the drug increased lifespan in mice, it also caused some negative effects, such as reduced bone mass. Moreover, alpelisib has side effects that could be problematic if used over the long term.
The significance of this study lies in its contribution to understanding aging mechanisms and its potential to treat age-related diseases. Alpelisib targets an enzyme called PI 3-kinase, which is linked to both cancer and aging.
Scientists have been researching drugs to target PI 3-kinase for over twenty years, mainly focusing on cancer treatment. This study suggests that such drugs might also help increase lifespan and improve metabolic health.
The researchers emphasize the need for further studies to fully comprehend alpelisib’s effects on aging and to assess any potential risks associated with its use. However, their findings mark an important step forward in the quest to enhance human health and longevity.
Alongside this study, other recent research highlights the benefits of various dietary and nutritional factors on aging.
For example, some studies suggest that animal protein may be more beneficial than plant protein for aging muscles. Another study found that olive oil could contribute to a longer life, while vitamin D has been shown to reduce the risk of autoimmune diseases.
These discoveries underscore the importance of ongoing research into aging and disease mechanisms. By exploring new treatments and therapies, scientists aim to improve human health and extend lifespan.
The study on alpelisib offers a promising avenue for future research and potential breakthroughs in the fight against aging and age-related diseases.
If you care about cancer, please read studies about vitamin D and bowel cancer, and a cautionary note about peanuts and cancer.
For more health information, please see recent studies about the link between ultra-processed foods and cancer, and everyday foods to ward off pancreatic cancer.
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