In two new studies, researchers showed cognitive impairment has been reported following recovery from COVID-19.
In the first study from the University of Texas, researchers examined chronic neuropsychiatric sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Data were included for 233 SARS-CoV-2-infected participants and 64 healthy people.
The researchers categorized the sample into three groups: normal cognition, memory-only impairment, and multiple-domain impairment (44.6%, 21.0% and 34.4%, respectively).
There was a link for the severity of cognitive impairment with the severity of olfactory dysfunction, but no correlation with severity of acute COVID-19.
In the second study from the University of Thessaly in Greece, researchers examined the prevalence and associations of cognitive impairment in 32 patients with mild-to-moderate COVID-19 followed for two months after hospital discharge.
They found that 56.2% of the patients presented with cognitive decline.
The predominant patterns of cognitive impairment were short-term memory impairments and multi-domain impairment without short-term memory deficits.
The team says a brain deprived of oxygen is not healthy, and persistent deprivation may very well contribute to cognitive difficulties.
These data suggest some common biological mechanisms between COVID-19’s dyscognitive effects and post-COVID-19 fatigue that have been reported over the last several months.
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The study was presented at the annual Alzheimer’s Association International Conference. One author of the study is Gabriel de Erausquin, M.D., Ph.D.
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