A new study shows that using tirzepatide together with menopause hormone therapy can lead to greater weight loss in postmenopausal women who are overweight or have obesity.
These findings were shared at the ENDO 2025 meeting, hosted by the Endocrine Society in San Francisco.
Tirzepatide is a medication used to help people lose weight and manage blood sugar. Menopause hormone therapy is often used to treat symptoms of menopause. According to the study, combining these two treatments leads to better weight loss results than using tirzepatide alone.
Dr. Regina Castaneda from the Mayo Clinic explained that this is the first study to show such results with tirzepatide and hormone therapy used together.
She pointed out that earlier studies showed similar results using semaglutide, another weight-loss drug, which suggests that combining hormone therapy with this class of medications may be especially effective for postmenopausal women.
After menopause, hormonal changes can lead to more belly fat, loss of muscle, and changes in how the body burns energy. These changes often cause weight gain and raise the risk of serious health problems like heart disease.
To test their idea, researchers studied medical records from 120 postmenopausal women over an average period of 18 months. Forty of these women used both tirzepatide and hormone therapy, while 80 used tirzepatide alone.
The results were clear. Women who used both treatments lost more weight overall — about 17% of their body weight — compared to 14% for women using tirzepatide only. Also, 45% of women using the combination treatment lost at least 20% of their body weight, compared to just 18% of women using only tirzepatide.
Dr. Maria Daniela Hurtado Andrade, also from the Mayo Clinic, said these findings are important for developing better and more personalized weight loss plans for postmenopausal women. She emphasized that more research is needed to understand exactly how hormone therapy and obesity medications work together.
She also noted that improving access to these combined treatments could help millions of women stay healthier and reduce their risk of weight-related health issues.
The study was supported by grants from the National Institutes of Health and the Mayo Clinic Center for Women’s Health Research.
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