A major international study led by researchers at McMaster University has identified the most effective and safest treatments for people living with chronic hives, also known as chronic urticaria.
This itchy, uncomfortable skin condition affects about 1 in 100 people and can significantly interfere with sleep, work, and daily life.
The findings, published on July 15, 2025, in the Journal of Allergy and Clinical Immunology, are the result of a large-scale analysis that compared more than 40 different treatment options.
The study is the first of its kind to comprehensively review and rank treatments using data from 93 clinical trials involving over 11,000 participants worldwide.
Until now, patients and doctors faced a confusing and constantly growing list of treatment options with little clear guidance.
This new research changes that by providing strong evidence about which treatments work best and which are safest.
The study found that omalizumab, an injectable antibody treatment, and remibrutinib, a newer oral medication, are among the most effective options for reducing the symptoms of chronic hives, including itching, swelling, and skin welts.
Another injectable treatment called dupilumab also showed strong results, particularly for reducing the appearance of hives.
Cyclosporine, a medication sometimes used when other treatments fail, was found to be effective but comes with a higher risk of serious side effects, such as kidney problems and high blood pressure. Because of this, it may be better suited for people who haven’t responded to safer options.
Dr. Derek Chu, the lead author of the study and an assistant professor at McMaster’s Department of Medicine, emphasized the importance of this research. He said the analysis gives patients and their healthcare providers a much-needed, evidence-based guide to choosing treatments that are both effective and safe.
These findings will be used to help update international treatment guidelines for chronic hives, giving doctors and patients clearer direction when managing the condition.
Chronic hives can be a frustrating and long-lasting condition, but this new research offers real hope by highlighting the treatments that are most likely to bring relief without serious risks. For anyone dealing with chronic hives, this study could be a game-changer in finding the right path to better health and comfort.
Source: McMaster University.
