Why do so many people refuse cholesterol-lowering statins?

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Heart disease is the leading cause of death in the United States, claiming a life every 34 seconds, according to the Centers for Disease Control and Prevention (CDC).

To help prevent heart attacks and strokes, doctors often prescribe statins, a type of medication that lowers bad cholesterol (LDL) in the blood. However, a new study has found that many high-risk patients refuse to take statins, raising concerns about how medical advice is received and followed.

A Surprising Study on Statin Refusal

Researchers from Brigham and Women’s Hospital, part of the Mass General Brigham health system, analyzed data from more than 24,000 patients at high risk of heart disease. These patients had conditions like diabetes, high cholesterol, or a history of stroke, all of which increase the risk of heart attacks.

Doctors recommended statins to all of these patients, but surprisingly, over 20% refused the medication. Some patients eventually agreed to take statins, but about one-third never started at all.

The study found that patients who refused statins took three times longer to lower their bad cholesterol levelscompared to those who started the medication immediately. Since high cholesterol is a key driver of heart disease, this delay likely put them at greater risk of heart attacks and strokes.

Why Are Women More Likely to Refuse Statins?

One of the most striking findings was that women were much more likely than men to refuse statins:

  • Women were 20% more likely than men to reject statins when their doctor first recommended them.
  • Women were 50% more likely to never take statins at all.

The researchers believe one reason for this may be a misconception that heart disease is primarily a men’s problem. In reality, heart disease is a leading cause of death for women as well, yet many women do not see themselves as being at risk.

Understanding Patient Concerns

Dr. Alex Turchin, one of the lead researchers, emphasized that doctors need to better understand why patients refuse statins. He believes open conversations about the risks and benefits of medication can help doctors provide patient-centered care that addresses individual concerns.

While some people may worry about side effects or question the necessity of medication, modern medicine has significantly improved both life expectancy and quality of life. Refusing recommended treatments could mean missing out on life-saving benefits.

What’s Next?

The findings, published in JAMA Network Open, raise important questions about how to improve communication between doctors and patients. Dr. Turchin is now studying the long-term effects of refusing statins, including whether it leads to higher rates of heart attacks, strokes, and death.

As researchers continue to explore these issues, one thing is clear: heart disease is a serious risk for both men and women, and proven treatments like statins can make a major difference in preventing it. Patients and doctors need to work together to ensure that life-saving medications are being used effectively.

If you care about heart health, please read studies that vitamin K helps cut heart disease risk by a third, and a year of exercise reversed worrisome heart failure.

For more health information, please see recent studies about supplements that could help prevent heart disease, stroke, and results showing this food ingredient may strongly increase heart disease death risk.

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