Diabetes drug metformin could protect against dementia

Credit: Unsplash+.

Type 2 diabetes is a long-term condition that affects how the body manages sugar in the blood. Normally, the body uses a hormone called insulin to keep blood sugar levels balanced.

But in type 2 diabetes, the body doesn’t make enough insulin or can’t use it well. As a result, sugar builds up in the blood, which can cause serious health problems over time, including issues with the brain.

One common medication for type 2 diabetes is metformin. It has been used for about 60 years to help control blood sugar levels.

Metformin works by reducing the amount of sugar the liver releases into the bloodstream and making the body’s cells respond better to insulin. It’s a widely used drug and has helped millions of people worldwide.

Recently, a study conducted by researchers at UNSW Sydney looked at how metformin might also help protect the brain. They found that people with type 2 diabetes who took metformin had slower memory loss and a lower risk of dementia compared to those who didn’t take the medication.

This finding is exciting because it suggests that metformin might not only help control blood sugar but also keep the brain healthier as people age.

The study involved 123 people with type 2 diabetes. Out of this group, 67 people were taking metformin to manage their blood sugar.

The researchers noticed that those taking metformin showed much less decline in their thinking and memory skills. They also had a smaller chance of developing dementia, which is a condition that affects memory, thinking, and decision-making.

This discovery is particularly important because dementia is a growing problem worldwide. Nearly 47 million people are living with dementia, and this number is expected to rise as the global population ages.

Finding ways to reduce the risk of dementia is a big focus for scientists and doctors, and this study gives hope that metformin could be one tool to help.

Interestingly, metformin has been studied for other health benefits in recent years. Some research suggests it may help with conditions like heart disease, certain cancers, and weight management.

It is also used to treat polycystic ovary syndrome (PCOS), a hormone-related condition. The fact that metformin might have benefits beyond diabetes management makes it a promising medication for further study.

While this research focused on people with type 2 diabetes, the findings raise the question of whether metformin could help people without diabetes who are at risk of memory problems or dementia.

The idea is still in its early stages, and more studies are needed to understand how metformin affects the brain and whether it could be used more widely for this purpose.

The researchers behind the study, led by Professor Katherine Samaras, are optimistic but cautious.

They emphasize that while the results are promising, metformin should not be seen as a cure for dementia. Instead, it may be one part of a larger strategy to support brain health, especially in people with type 2 diabetes.

The study was published in the journal Diabetes Care. As researchers continue to explore metformin’s effects, there’s hope that this common diabetes medication might offer even more benefits than we previously thought, potentially helping millions of people maintain better brain health as they age.

If you care about brain health, please read studies about how the Mediterranean diet could protect your brain health, and Omega-3 fats and carotenoid supplements could improve memory.

For more information about brain health, please see recent studies about antioxidants that could help reduce dementia risk, and higher magnesium intake could help benefit brain health.

Copyright © 2024 Knowridge Science Report. All rights reserved.