Using cannabis can cause strong genetic changes

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As marijuana gains legal status and popularity across various parts of the United States, understanding its impact on health becomes increasingly important.

Recent data indicates that around 18% of Americans have tried marijuana at least once, signaling a shift in societal attitudes towards cannabis use.

However, despite its growing acceptance, the scientific community is still uncovering how marijuana use affects our bodies and health over time.

Marijuana, a mixture of dried leaves from the Cannabis sativa plant, is consumed in several ways, including smoking, vaporizing, or as an ingredient in food and drinks.

With nearly 48.2 million Americans reported to have used marijuana in 2019, it stands as the most commonly used drug in the country, according to the Centers for Disease Control and Prevention.

In light of marijuana’s widespread use, researchers at Northwestern Medicine embarked on a study to delve into the biological effects of consuming cannabis. Dr. Lifang Hou, a cancer research specialist, led a team that analyzed blood samples from over 900 adults, collected five years apart.

These participants were initially part of a study focused on heart health. By inquiring about their recent and lifetime marijuana use, and examining DNA within their blood samples, the researchers aimed to uncover any significant changes.

The study’s findings revealed intriguing insights into DNA methylation, a process where small chemical groups attach to DNA, potentially influencing gene activity.

The researchers identified between 16 and 132 DNA methylation markers associated with marijuana use, notably in regions related to cell growth, hormone signaling, infections, and mental health issues, such as schizophrenia, bipolar disorder, and substance use disorders.

While these findings do not definitively prove that marijuana use causes these genetic changes or leads to specific health problems, they establish a correlation that warrants further investigation.

This connection could pave the way for future research into the long-term effects of marijuana use on human health, particularly in understanding how it may influence genetic expression and contribute to various conditions.

The study, published in Molecular Psychiatry, underscores the need for continued exploration into the consequences of marijuana use, especially as its prevalence increases.

With more states legalizing cannabis for medical and recreational purposes, it’s vital that research keeps pace, offering insights that can inform public health policies and individual choices regarding marijuana consumption.

As the debate over marijuana’s benefits and risks continues, studies like this highlight the complexity of understanding cannabis’s impact on health.

While the potential therapeutic uses of cannabis and its derivatives, such as CBD, are being explored for conditions like depression, Alzheimer’s disease, and even COVID-19 infection, it’s crucial that we also consider the broader implications of widespread marijuana use on genetic and health outcomes.

In conclusion, this research adds a significant piece to the puzzle of how marijuana use affects our bodies, emphasizing the importance of cautious and informed engagement with cannabis as both its legal status and social acceptance evolve.

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