Inflammation in the brain may play crucial role in early Parkinson’s disease

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Researchers from the University of Alabama at Birmingham have made a significant discovery regarding Parkinson’s disease. They found that inflammation in the brain is present during the early stages of the disease.

This revelation suggests that inflammation might be a key factor in both the onset and progression of Parkinson’s disease, potentially opening new avenues for understanding the condition and developing treatments.

The Study Explained

The research team, led by Professor Talene Yacoubian from the Department of Neurology, conducted a study involving 58 individuals who were recently diagnosed with Parkinson’s disease and 62 individuals without the disease for comparison.

Importantly, the study focused on individuals who had not yet started any Parkinson’s medications, allowing researchers to investigate whether inflammation naturally occurs in the early stages of the disease.

To identify signs of brain inflammation, the researchers utilized PET imaging—a specialized body scanning technique.

They injected a radioactive molecule into the bloodstream, which binds to a protein called TSPO primarily found in brain cells responsible for immune responses. During the scan, this protein becomes visible when there is inflammation.

The study’s findings were striking: individuals in the early stages of Parkinson’s disease exhibited higher levels of the inflammation-marker protein compared to those without the disease.

This suggests that inflammation occurs independently of any Parkinson’s treatment and may be inherent in the disease from the outset.

What Does This Mean for the Future?

While this discovery is a significant step forward, many questions remain unanswered. Researchers are now seeking to understand whether the level of inflammation changes as the disease progresses and whether it can predict the rate of disease advancement.

To find these answers, the study will continue to monitor participants for up to five years, conducting follow-up scans and tracking disease progression.

By focusing on the role of inflammation in the early stages of Parkinson’s disease, researchers aim to unlock new avenues for treatment. Their ultimate goal is to find ways to slow down or halt the progression of this challenging disease.


Inflammation in the brain may emerge as a crucial factor in the early stages of Parkinson’s disease, according to this groundbreaking study.

While more research is needed to fully understand the implications, this discovery offers hope for innovative approaches to diagnosis and treatment that target inflammation in Parkinson’s disease.

If you are concerned about inflammation, you may be interested in studies on the primary cause of inflammation in common bowel diseases and how vitamin B might help combat COVID-19 and reduce inflammation.

For those interested in nutrition, recent research explores a new approach to halting excessive inflammation and identifies foods that may contribute to inflammation.

The research findings can be found in Movement Disorders.

If you care about health, please read studies that vitamin D can help reduce inflammation, and vitamin K could lower your heart disease risk by a third.

For more information about health, please see recent studies about new way to halt excessive inflammation, and results showing foods that could cause inflammation.

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