Brain has its own cannabinoid molecules as stress coping mechanism

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A groundbreaking study by Northwestern Medicine reveals that the brain releases its own cannabinoid molecules in stressful situations.

These molecules, produced by the amygdala, may serve to dampen stress signals from the hippocampus, a memory and emotion center in the brain.

The study, which was conducted on mice, adds to the understanding of how our brains cope with stress at a molecular level.

Research Methodology

The study, titled “Endocannabinoid release at ventral hippocampal-amygdala synapses regulates stress-induced behavioral adaptation,” appeared in the journal Cell Reports.

For this research, scientists employed a novel protein sensor that could detect these cannabinoid molecules at particular brain synapses in real-time.

This sensor revealed that these molecules were released in response to various types of stress.

Findings and Their Implications

When researchers removed the targeted cannabinoid receptor type 1, mice demonstrated a reduced capacity to cope with stress and motivational deficits.

Specifically, these mice had a lower preference for sweetened sucrose water after exposure to stress, which might be analogous to the reduced pleasure sensation often experienced by humans with stress-related disorders.

Dr. Sachi Patel, the chair of psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine and the study’s corresponding author, said, “Understanding how the brain adapts to stress at the molecular, cellular, and circuit level could provide critical insight into how stress translates into mood disorders.”

Potential for Stress-Related Disorder Treatment

One of the most promising areas for new drug development targeting stress-related disorders like anxiety, depression, and PTSD is the endocannabinoid system, according to Dr. Patel.

The study suggests that impairments in the brain’s endogenous cannabinoid signaling system could make individuals more susceptible to developing these conditions, although this still needs to be verified in humans.

Future Steps

“Determining whether increasing levels of endogenous cannabinoids can be used as potential therapeutics for stress-related disorders is a next logical step from this study,” said Dr. Patel.

There are ongoing clinical trials investigating this area, which could offer answers in the near future.


This groundbreaking research adds a new layer to our understanding of how the brain responds to stress and points to the endocannabinoid system as a potential therapeutic target for stress-related disorders.

While more work is needed to confirm these findings in humans, the study opens the door to novel treatment possibilities.

If you care about brain health, please read studies about a key to activating ‘fountain of youth’ in brain, and how COVID-19 triggers an immune response in the brain.

For more information about brain health, please see recent studies about heartburn drugs that could increase the risk of dementia, and results showing this MIND diet may protect your cognitive function, and prevent dementia.

The research findings can be found in Cell Reports.

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