New way to find best diet for your weight loss

Credit: Unsplash+

A recent analysis of a yearlong weight-loss study has uncovered essential behaviors and biomarkers that contribute to both short-term and long-term weight loss.

While strict adherence to a healthy low-carb or low-fat diet played a crucial role in short-term weight loss, maintaining long-term weight loss for a year involved factors beyond calorie counting and exercise.

The study highlights the significant influence of gut bacteria, specific proteins in the body, and metabolic biomarkers in predicting individual success in losing and maintaining weight.

Short-Term vs. Long-Term Weight Loss

The study involved 609 participants who meticulously recorded their dietary habits while following either a low-fat or low-carb diet, consisting primarily of high-quality, minimally processed foods, for a year.

The initial findings revealed that short-term weight loss during the first six months was primarily influenced by strict diet adherence, irrespective of whether it was low-carb or low-fat.

However, long-term success in maintaining weight loss for a year appeared to be more complex.

Understanding the Biomarkers

The research team delved into biomarkers of metabolism to decipher the intricacies of long-term weight management.

Specific microbiome compositions, protein levels, and metabolic signatures measured at the study’s onset provided valuable insights into individual weight loss outcomes.

Among the biomarkers examined, the ratio of inhaled oxygen to exhaled carbon dioxide, known as the respiratory quotient, emerged as a significant factor. This ratio indicates whether the body primarily uses carbohydrates or fats as fuel.

Those with higher initial respiratory quotients experienced greater weight loss on low-carb diets, highlighting the importance of metabolic preferences.

Personalized Diets: The Future of Weight Loss

The study’s findings pave the way for personalized weight loss strategies based on gut microbiome composition, proteomic analysis, and metabolic signatures.

While such personalized biomarker-based diets are not yet widely available, they hold promise for tailoring weight loss plans to individual needs and preferences.

Tracking specific gut microbe strains may become a valuable tool for choosing the most effective diet for an individual.

Until personalized biomarker-based diets become accessible, the study underscores the importance of focusing on high-quality, unprocessed foods while reducing refined flours and sugars.

Specific nutrient correlations with weight loss during the first six months were identified:

  • Low-Carb Diets: Emphasize monounsaturated fats from sources like avocados and prioritize vitamins K, C, and E found in vegetables, nuts, olives, and avocados.
  • Low-Fat Diets: Prioritize fiber-rich foods such as whole grains and beans while avoiding added sugars.

Mindset Shift: Quality Over Quantity

The researchers advocate shifting the focus from calorie counting to quality food choices.

Instead of fixating on exclusionary diets, individuals should seek ways to incorporate more fiber, whether from beans, whole grains, nuts, or vegetables, into their diets.

Learning to cook and relying less on processed foods can also contribute to successful long-term weight management.

Ultimately, the study suggests that paying attention to food quality and nutritional content can render calorie counting unnecessary.


The study’s groundbreaking insights into gut bacteria, biomarkers, and metabolic preferences shed light on the complexities of weight loss.

While personalized diets based on these biomarkers remain on the horizon, the current emphasis should be on consuming high-quality, unprocessed foods and adopting a mindset that prioritizes the inclusion of nutritious elements in one’s diet.

This research offers a glimpse into the future of personalized weight loss strategies, providing hope for more effective and sustainable approaches to managing weight.

If you care about weight, please read studies about diet that can treat fatty liver disease, obesity, and hop extract could reduce belly fat in overweight people.

For more information about weight, please see recent studies about how to curb your cravings for ready-to-eat foods, and results showing what you can eat to speed your metabolism up.

The research findings can be found in the journal Cell Reports Medicine.

Follow us on Twitter for more articles about this topic.

Copyright © 2023 Knowridge Science Report. All rights reserved.