Chronic kidney disease affects body weight after weight loss surgery

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A recent study published in Obesity Surgery sheds light on the influence of early-stage chronic kidney disease (CKD) on weight loss outcomes following bariatric metabolic surgery.

Led by João Pereira from the University of Porto in Portugal, the research aimed to assess how kidney dysfunction affects the success of weight loss outcomes in patients undergoing gastric bypass surgery.

The study involved 127 participants who underwent gastric bypass surgery. These patients underwent preoperative evaluations and follow-up assessments at six and twelve months post-surgery to track their weight loss progress.

The researchers specifically looked at the impact of various kidney function parameters on weight loss outcomes.

Following bariatric metabolic surgery, participants experienced significant weight loss.

The mean body mass index (BMI) dropped from 39.6 kg/m² before surgery to 27.7 kg/m² at six months and 25.0 kg/m² at twelve months.

One notable finding was that individuals with a preoperative estimated glomerular filtration rate (eGFR) lower than the 25th percentile exhibited lower total weight loss percentages compared to those with healthier kidney function.

Specifically, at twelve months after surgery, those with lower eGFR achieved a total weight loss of 34.4%, while those with better kidney function achieved a total weight loss of 39.4%.

However, the study did not find significant correlations between weight loss metrics and other kidney function parameters, including preoperative creatinine clearance rate, proteinuria, or albuminuria.

Implications and Future Research

The study’s findings suggest that individuals with obesity who also have early-stage deterioration of kidney function (CKD stage G2) can still achieve satisfactory weight loss outcomes after bariatric metabolic surgery.

Moreover, these patients may potentially benefit from improvements in renal function, as previously reported in other studies.

It’s important to note that this study primarily focused on short-term weight loss outcomes (up to twelve months after surgery).

Therefore, further research is needed to confirm whether these findings hold over a longer period.

Understanding the relationship between kidney function and weight loss following bariatric surgery can provide valuable insights for healthcare professionals and individuals considering these procedures.

If you care about kidney health, please read studies about drug that prevents kidney failure in diabetes, and drinking coffee could help reduce risk of kidney injury.

For more information about kidney health, please see recent studies about foods that may prevent recurrence of kidney stones, and common painkillers may harm heart, kidneys and more.

The research findings can be found in Obesity Surgery.

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