The hidden link between inflammation and weight loss surgery success

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The Big Problem: Obesity and Its Cost

Obesity is a growing problem, not just for individual health but also for healthcare systems. In the UK, the National Health Service (NHS) spends about £6 billion a year on obesity-related issues.

By 2050, that cost is expected to go up to almost £10 billion. Weight loss surgeries, like shrinking the stomach, are one of the ways people try to fight obesity.

These surgeries are expensive, ranging from £4,000 to £10,000, and their results can differ a lot from person to person.

So, researchers are digging deep to find out what factors might predict who will benefit the most from these procedures.

The Study: Linking Inflammation, Depression, and Weight Loss Surgery

A team of researchers from King’s College London looked into a new angle—how inflammation and depression relate to the success of weight loss surgery.

In this first-of-its-kind study, they examined 85 people going through this surgery. They checked for signs of depression and measured the levels of substances in the blood that show how much inflammation is happening in the body.

Interestingly, they found that the people who had both obesity and signs of depression also had higher levels of inflammation.

After the surgery, most people lost weight as expected, and many who were depressed felt better.

But those who had higher inflammation levels before surgery didn’t lose as much weight six months later compared to those with lower inflammation levels.

Why It Matters: Better Support and Targeted Treatments

Lead researcher Valeria Mondelli says this study opens doors for better patient care.

For example, knowing that high inflammation levels could be a hurdle in weight loss after surgery can guide doctors to design more personalized treatment plans.

These might include medicines or therapies to reduce inflammation.

Another key finding was that a person’s childhood experiences and pre-existing depression were better at predicting whether they would still be depressed after the surgery.

This suggests that some patients might need extra emotional support along with their medical treatment.

Dr. Anna McLaughlin, one of the study authors, added that this research shows how crucial it is to look at both medical data like inflammation levels and personal factors like past trauma to improve surgery outcomes.

By doing so, healthcare providers can better identify who might need additional help, either through medication to reduce inflammation or through extra psychological support.

In a nutshell, this study shows us that fighting obesity isn’t just about diet, exercise, or even surgery. It’s a complex issue that involves various factors, including inflammation and mental health.

By understanding these hidden links, healthcare providers can make sure that expensive treatments like weight loss surgeries give people the best shot at a healthier future.

If you care about weight loss, please read studies that avocado could help you lose weight and belly fat, and a keto diet for weight loss can cause flu-like symptoms.

For more information about nutrition, please see recent studies about unhealthy plant-based diets linked to metabolic syndrome, and these antioxidants could help reduce dementia risk.

The study was published in Psychological Medicine.

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