Scientists find a big cause of Alzheimer’s disease

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Alzheimer’s disease is a common condition affecting many older people across the globe, leading to memory loss and major changes in behavior, known as dementia.

For over twenty years, scientists have been on a quest to understand the causes of Alzheimer’s. Unfortunately, a precise cause and a cure remain elusive. Generally, people have believed there might be two main causes for Alzheimer’s disease.

Possible Causes:

Protein Buildup: One belief is that a specific protein, called amyloid-beta, builds up in the brain and causes Alzheimer’s.

Cell Energy Issues: A newer thought is that the issues in the energy-producing parts of our cells, known as mitochondria, might be responsible for Alzheimer’s.

Researchers from Yale-NUS College recently conducted a study which sheds more light on the second theory, suggesting issues with cell energy might indeed be linked to Alzheimer’s.

To study this, they used a tiny worm, Caenorhabditis elegans, which is surprisingly similar to human cells at a molecular level.

They found that the worms showed signs of metabolic defects, which are related to how our bodies use energy, before there was any notable increase in the troublesome protein, amyloid-beta.

Interestingly, when they treated the worms with Metformin, a medication commonly used for diabetes, these metabolic defects reversed, and the worms showed improvements in their health and lifespan.

This finding is pivotal because it suggests that addressing metabolic defects early on could possibly prevent the progression of Alzheimer’s disease.

A New Perspective

Researchers are now suggesting that instead of treating Alzheimer’s after it has developed, it might be more beneficial to target and address aging mechanisms directly, possibly preventing Alzheimer’s and other age-related diseases.

Aging inherently brings metabolic and mitochondrial dysfunction, and it might be that Alzheimer’s is a manifestation of such aging processes.

Preventing Alzheimer’s:

While there is no guaranteed method to prevent Alzheimer’s, here are some lifestyle changes that can reduce the risk of developing this disease:

Regular Exercise: Engaging in regular physical activity can lower the risk by up to 50%.

Healthy Diet: Consuming a balanced diet rich in fruits, vegetables, lean proteins, and healthy fats can protect the brain.

Mental Stimulation: Keeping the brain active and engaged, through learning new skills or hobbies, can be beneficial.

Adequate Sleep: Proper sleep is crucial for maintaining brain health and can lower the risk.

Stress Management: Managing stress through healthy means like exercise or meditation can prevent potential damage to the brain.

Social Engagement: Maintaining a strong social network can fend off the risk associated with social isolation.

Head Protection: Protecting the head from injuries by using helmets in sports and preventing falls can also be significant.

Following these steps cannot ensure complete protection against Alzheimer’s but can significantly improve overall well-being and lower the risk of Alzheimer’s disease.

In conclusion, the quest for understanding Alzheimer’s continues, with newer research pointing towards addressing aging mechanisms directly to prevent this and other age-related conditions.

Adopting a healthy lifestyle plays a critical role in reducing the risk, and further research might open new pathways for understanding and managing Alzheimer’s more effectively.

The work of Jan Gruber and team, published in eLife, is a step forward in this ongoing journey to understand and combat Alzheimer’s disease.

If you care about Alzheimer’s, please read studies about Vitamin D deficiency linked to Alzheimer’s, vascular dementia, and Oral cannabis extract may help reduce Alzheimer’s symptoms.

For more information about brain health, please see recent studies that blueberry supplements may prevent cognitive decline, and results showing higher magnesium intake could help benefit brain health.

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