“Good” cholesterol and high blood pressure: Genetic links to Alzheimer’s

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Unpacking the Research

In a recent study, published in the prestigious journal JAMA Network Open, a team of scientists made a remarkable discovery linking high-density lipoprotein (HDL) cholesterol and high systolic blood pressure with an increased risk of developing Alzheimer’s disease (AD).

This research was conducted by Dr. Jiao Luo and her team at Copenhagen University Hospital-Rigshospitalet, Denmark.

Understanding Alzheimer’s Disease

Alzheimer’s disease is a progressive neurological disorder that affects memory, thinking, and behavior.

It’s the most common cause of dementia, a term for a group of symptoms associated with a decline in mental capabilities.

AD typically affects people over the age of 65, but early-onset forms of the disease can start affecting individuals as early as their 40s.

The Power of Genetics in Understanding Alzheimer’s

The study utilized a technique known as Mendelian randomization. This method leverages genetic information to determine potential cause-and-effect links between risk factors and diseases.

Essentially, it uses genetic variants associated with modifiable risk factors (like diet or smoking) as proxies to estimate the effect of these factors on disease outcomes.

The power of Mendelian randomization lies in the fact that the genetic variants used in the analysis are determined at conception and remain constant throughout a person’s life.

This means they are free from confounding factors and reverse causation, issues that often challenge traditional observational studies.

Study Design and Participants

In this particular study, the researchers selected genetic variants associated with modifiable risk factors for Alzheimer’s disease as their instrumental variables.

They then compared these variables with outcome data gathered from the European Alzheimer & Dementia Biobank (EADB).

The researchers worked with two sets of participants. The first included 39,106 individuals who had received a clinical diagnosis of AD.

The second group served as a control group and comprised 401,577 individuals who had no diagnosis of Alzheimer’s disease.

Results: HDL Cholesterol and Systolic Blood Pressure

The research team discovered a notable link between genetically determined HDL cholesterol levels and the odds of developing Alzheimer’s disease.

They found that for every one-standard-deviation (one-SD) increase in HDL cholesterol concentrations, there was a 10% increase in the odds of developing AD.

They also observed an association between genetically determined high systolic blood pressure and an increased risk for Alzheimer’s disease.

When they adjusted their analysis to account for diastolic blood pressure, they found that every 10-mm Hg increase in systolic blood pressure was linked to a 22% increase in the risk for AD.

To ensure the robustness of their results, the researchers performed a second analysis designed to reduce bias due to overlapping samples.

This follow-up analysis confirmed the original results.

The team found that similar odds for developing Alzheimer’s disease were associated with HDL cholesterol and systolic blood pressure, with an 8% increase per one-SD unit increase in HDL cholesterol and a 23% increase per 10-mm Hg rise in systolic blood pressure.

Impact and Future Applications

The results of this study are not only intriguing but potentially far-reaching in terms of their applications.

The links found between genetically determined high HDL cholesterol, high systolic blood pressure, and the odds of developing Alzheimer’s disease could inspire the development of new drug targets and strategies for early prevention of dementia.

Furthermore, this research highlights the power and potential of using genetic data to uncover new risk factors for diseases and understand their underlying biological mechanisms.

However, it is important to note that several authors disclosed financial ties to the biopharmaceutical industry.

If you care about Alzheimer’s disease, please read studies about vitamin D deficiency linked to Alzheimer’s, vascular dementia. and findings of Omega-3 fats and carotenoid supplements could improve memory.

For more information about brain health, please see recent studies about antioxidants that could help reduce dementia risk, and Coconut oil could help improve cognitive function in Alzheimer’s disease.

The study was published in JAMA Network Open.

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