A new test for detecting bladder cancer has been created by researchers at the University of Birmingham and cancer detection and screening company Nonacus.
The test, named GALEAS Bladder, is a non-invasive urine-based molecular test that can accurately detect bladder cancer and reduce the need for invasive cystoscopies.
The test uses a combination of liquid biopsy technology and biomarkers developed by Professor Rik Bryan and Dr. Douglas Ward from the University’s Bladder Cancer Research Center.
It detects the presence of bladder cancer by finding DNA from tumor cells in the urine.
It has been validated with over 600 patient samples from 3 UK clinical cohorts, showing high diagnostic accuracy across all stages and grades of bladder cancer.
Professor Bryan explained that they have been working on different strategies to accurately detect bladder cancer from urine samples since 2009, and with funding from Cancer Research UK and support from Nonacus, they have been able to create a test that appears to be as effective as cystoscopy.
In addition, the researchers found that the same mutation panel and Nonacus platform used in GALEAS Bladder can also identify circulating tumor DNA, meaning that a single approach can potentially be used throughout the patient pathway.
The GALEAS Bladder test has the potential to work across the entire bladder cancer patient pathway, reducing the need for invasive cystoscopies and expensive imaging for non-muscle-invasive bladder cancer surveillance and minimal residual disease monitoring, as well as triage for hematuria (blood in urine).
Chris Sale, CEO of Nonacus, stated that they are excited to launch GALEAS Bladder and are striving to develop non-invasive tools that can make a real impact on the diagnosis and treatment of patients with suspected cancer.
The GALEAS Bladder test is the first in their pipeline, and it will help improve patients’ lives and reduce the burden of cystoscopy on clinics.
Bladder cancer is the 10th most common cancer in the world, and it has a high recurrence rate. Early detection and diagnosis is crucial for the successful treatment of the disease.
The GALEAS Bladder test provides a quick, accurate, and non-invasive method for detecting bladder cancer, making it a valuable tool in the fight against the disease.
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