Researchers from the University of Oslo have developed an artificial intelligence (AI) method that can help identify potential new medicines for Alzheimer’s disease.
The researchers discovered that one of the causes of Alzheimer’s disease is the degeneration and loss of nerve cells in the brain as we age.
As a cell is like finely tuned machinery, it needs the energy to perform its tasks. The energy comes from energy factories called mitochondria.
In young and healthy cells, old or damaged mitochondria are removed from the cell in a process called mitophagy.
However, in older people, they tend to have more broken mitochondria, and their cells will not be able to remove all of them anymore.
An accumulation of broken mitochondria clogs the cell’s ordinary processes, and eventually, the cell will die.
To address this issue, the researchers looked into the use of so-called mitophagy inducers to boost the cleaning process.
They searched for substances that could induce the cleaning process and used AI to search for substances similar to known mitophagy inducers.
The computer program browsed through a large catalog of substances and identified two candidates, rhapontigenin and kaempferol.
The team used mice and nematodes, a type of worms, to test whether these substances inhibited memory loss in their nerve cells.
The researchers found that their new medicine is more precise, and no side effects were documented during tests with worms and mice.
They discovered that rhapontigenin and kaempferol may help delay the progression of memory loss and reduce disease progression when it has occurred.
They also filed a patent on rhapontigenin for the treatment of Alzheimer’s disease.
Alzheimer’s disease is a progressive disorder that affects memory, thinking, and behavior. It is the most common cause of dementia among older adults.
Although there is no known cure for Alzheimer’s, the development of new treatments can improve the quality of life for people with the disease.
The researchers’ work is an important step towards developing new medicines for Alzheimer’s and highlights the potential of AI to help identify new drugs.
The team’s ongoing work in describing the molecular mechanisms that help rhapontigenin and kaempferol induce mitophagy will provide valuable insights into the development of new treatments for Alzheimer’s and other neurodegenerative diseases.
While there is no known cure for Alzheimer’s disease, there are several things you can do to potentially reduce your risk or delay the onset of symptoms. Here are some tips:
Stay physically active: Regular exercise can help improve blood flow to the brain, promote the growth of new brain cells, and reduce inflammation, all of which may help reduce your risk of Alzheimer’s.
Eat a healthy diet: A diet rich in fruits, vegetables, whole grains, and healthy fats, such as those found in fish, nuts, and olive oil, may help protect the brain and reduce the risk of Alzheimer’s.
Stay mentally active: Keeping your brain active through activities like reading, learning a new language, or solving puzzles may help reduce the risk of Alzheimer’s.
Manage chronic conditions: Conditions like high blood pressure, high cholesterol, and diabetes can increase the risk of Alzheimer’s, so it’s important to manage these conditions through lifestyle changes and medication if necessary.
Stay socially engaged: Socializing and staying connected with friends and family may help reduce the risk of Alzheimer’s and improve overall brain function.
Get enough sleep: Chronic sleep deprivation may increase the risk of Alzheimer’s, so it’s important to prioritize getting enough quality sleep each night.
Protect your head: Traumatic brain injury can increase the risk of Alzheimer’s, so it’s important to wear a helmet when engaging in high-risk activities like cycling or skiing.
While these tips may help reduce the risk of Alzheimer’s, it’s important to remember that the disease can still develop despite taking these preventative measures.
If you or a loved one is experiencing symptoms of Alzheimer’s, it’s important to seek medical attention and a proper diagnosis.
If you care about dementia, please read studies about how the Mediterranean diet could protect your brain health, and Vitamin B supplements could help reduce dementia risk.
For more information about brain health, please see recent studies that cranberries could help boost memory, and many older people have this non-Alzheimer’s dementia.
The study was conducted by Evandro F. Fang. et al.
Copyright © 2023 Knowridge Science Report. All rights reserved.