In a study from Brown University, scientists found higher intake of manganese is linked to a lower type 2 diabetes risk among postmenopausal women, independent of known risk factors.
They evaluated the association between manganese intake and the risk for type 2 diabetes in 84,285 older women without a history of diabetes.
The researchers found that compared with the lowest intake of dietary manganese, people in the highest quintile had a lower risk for type 2 diabetes. These findings were confirmed in another group of people.
In 3,749 women with information on biomarkers of inflammation and endothelial dysfunction, the team found higher dietary manganese intake was linked to lower levels of inflammatory biomarkers that strongly mediated the link between dietary manganese and type 2 diabetes risk.
The team also found in type 2 diabetes risk due to manganese, 19% of the risk was mediated through interleukin 6 and 12 percent through high-sensitivity C-reactive protein.
They suggest that eating foods rich in manganese could potentially be targeted for intervention against type 2 diabetes risk in older women.
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The study was conducted by Jung Ho Gong et al and published in Diabetes Care.
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