Exercise may slow down cognitive decline in Parkinson’s disease

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For people with Parkinson’s disease, problems with thinking and memory skills are among the most common nonmotor symptoms of the disease.

In a study from Hallym University in Seoul, scientists found that exercise may help slow cognitive decline for some people with the disease.

Research has suggested that people with Parkinson’s who have the gene variant apolipoprotein E e4, or APOE e4, may experience faster cognitive decline and earlier in the disease than people without the variant.

APOE e4 is known as a genetic risk factor for Alzheimer’s disease. The study looked at whether exercise could play a role in slowing cognitive decline for people with APOE e4.

In the study, the team examined 173 people with early Parkinson’s disease who were on average 63 years old at the time and 59 years old when they developed the disease.

A total of 27% had the APOE e4 gene variant.

People reported their physical activity with a questionnaire on how much activity they had in the previous week through leisure activities such as walking or biking, household activities such as dusting or yard work, and work activities for pay or as a volunteer.

People took a test of their thinking skills at the beginning of the study and then one and two years later. Overall, scores at the beginning of the study averaged 26 points.

For people with the APOE e4 gene variant, test scores declined by an average of 1.33 points by the end of the study compared to those without the variant.

But researchers also found that greater physical activity at the start of the study lessened APOE e4-related cognitive decline two years later by an average of 0.007 points.

These results support the use of interventions that target physical activity as a way to delay cognitive decline in people with early Parkinson’s who have the APOE e4 gene variant.

A limitation of the study was that participants reported their own levels of physical activity, so there is the possibility that they would not remember their levels exactly.

If you care about Parkinson’s disease, please read studies about a better way to treat Parkinson’s disease, and Vitamin E may help prevent Parkinson’s disease.

For more information about brain health, please see recent studies that Parkinson’s disease is on your skin, and results showing flavonoid-rich foods could improve survival in Parkinson’s disease.

The study was conducted by Jin-Sun Jun et al and published in Neurology.

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