Scientists from the University of Otago are closer to preventing immature death and improving the overall health of people with diabetes.
More than 60% of people worldwide with type 2 diabetes die from some sort of heart disease.
The researchers have been working to develop a treatment for people with type 2 diabetes who develop heart disease.
Previously, the group identified molecular regulators (microRNA) which play a major role in the development of heart disease and modified them before they changed, to prevent the disease in diabetics.
However, in reality, and in clinics, scientists do not see patients before they develop any form of the disease. In fact, people don’t go to their doctors or hospital unless there is a problem.
Using mouse models, which react in a similar way to humans with type 2 diabetes, the team set out to treat heart disease.
They identified that our treatment was able to restore heart function by reducing the death of heart cells.
The team was able to initiate the treatment after the development of the disease but still improve the heart function. This result shows confidence that microRNA therapy can be used in clinics.
It will improve the health of people with type 2 diabetes and reduce immature death. The next stage of the project is to test if there will be similar improvements in larger animal models.
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The research was published in Molecular Therapy—Nucleic Acids and conducted by Associate Professor Rajesh Katare et al.
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