Scientists from Aizawa Hospital in Japan found that people who develop diabetes or prediabetes have elevated fasting plasma glucose (FPG) at least 10 years before diagnosis.
The research was published in the Journal of the Endocrine Society and was conducted by Hiroyuki Sagesaka et al.
In the study, researchers analyzed data from 27,392 health examinees without diabetes for a mean of 5.3 years.
Ten years before the diagnosis of prediabetes (4,781 participants) or diabetes (1,061 participants), the participants’ insulin sensitivity was tested.
The researchers found that 10 years before diagnosis, BMI was much higher in individuals who developed diabetes, while insulin sensitivity was lower than among those who did not develop diabetes.
At 10 years before diagnosis, these measurements were slightly but significantly different in participants who developed prediabetes versus those who did not develop prediabetes.
Toward the time of diabetes or prediabetes diagnosis, the differences were progressively greater.
These findings suggest that blood sugar dysregulation can be seen years before diabetes diagnosis.
Because trials of prevention in people with prediabetes seem to be less successful over long-term follow-up, we may need to intervene much earlier than the prediabetes stage to prevent progression to full-blown diabetes.
A much earlier intervention, either drug or lifestyle related, is warranted.
If you care about diabetes, please read studies about a new way to achieve type 2 diabetes remission, and one avocado a day keeps diabetes at bay.
For more information about diabetes, please see recent studies about 5 dangerous signs you have a diabetes-related eye disease and results showing why pomegranate is super fruit for people with diabetes.
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