Scientists from the University of Alberta found that a combination of drugs for obesity and type 2 diabetes may be more effective than a single therapy.
They are trying to identify new drug combinations to treat people with obesity and type 2 diabetes.
The goal is to develop personalized prescriptions that are more effective than single drugs and that can potentially replace more invasive treatments such as bariatric surgery, especially for children.
The research is published in Frontiers in Endocrinology and was conducted by Andrea Haqq et al.
In the study, the team examined the potential of several drugs that control incretins.
These metabolic hormones stimulate the body to produce insulin and use it effectively. They also suppress appetite in order to control blood sugars and reduce weight.
The researchers found that combining the drugs has several advantages, including higher effectiveness in at least some patients and fewer side effects.
Even a five percent weight loss is considered clinically meaningful, and patients in some of the combination drug trials are achieving 10 or 15 percent.
The researchers recommend further research to identify why some individuals respond differently to the drugs.
Some racial and ethnic groups bear a disproportionate burden of obesity and type 2 diabetes, so more participants from these groups are needed in trials.
Further studies should also focus on how differences in biological sex affect drug efficacy and safety.
In addition to drug combinations, the researchers are looking for non-pharmacological solutions, such as how adding fiber to a person’s diet can slow weight gain and improve the effectiveness of existing diabetes medications.
If you care about diabetes, please read studies about a promising new way to treat type 2 diabetes, and Zinc may be key to better diabetes treatments.
For more information about diabetes, please see recent studies about why do people with diabetes develop severe COVID-19, and results showing this diabetes drug can help people lose weight effectively.
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