Throughout the COVID-19 pandemic, clinicians have noted that certain patients are at especially high risk of developing severe illness or dying from coronavirus infection.
Type 2 diabetes—a condition affecting more than 10 percent of the U.S. population– is one of the main risk factors for severe COVID-19 illness.
In a new study from the University of Michigan, researchers found why this might be and offer hope for potential therapy.
The culprit appears to be an enzyme called SETDB2. This same enzyme has been implicated in the non-healing, inflammatory wounds found in people with diabetes.
The team used a mouse model of coronavirus infection, and they found that SETDB2 was decreased in immune cells involved in the inflammatory response, called macrophages, of infected mice with diabetes.
They later saw the same thing in monocyte-macrophages in the blood from people with diabetes and severe COVID-19.
In the mouse and human models, as SETDB2 went down, the inflammation went up. In addition, they revealed that a pathway known as JAK1/STAT3 regulates SETDB2 in macrophages during coronavirus infection.
Taken together, the results point to a potential therapeutic pathway.
Previous findings from the lab demonstrated that interferon, a cytokine important for viral immunity, increased SETDB2 in response to wound healing.
In the new study, they found blood serum from patients in the ICU with diabetes and severe COVID-19 had reduced levels of interferon-beta compared to patients without diabetes.
The team also found that if they administered interferon beta to coronavirus-infected diabetic mice, they were able to increase SETDB2 and decrease inflammatory cytokines.
The researchers hope the findings of this study will inform ongoing clinical trials of interferon or other downstream components of the pathway, including epigenetic targets, for COVID-19.
Their work also highlights the need to understand the timing and cell-specificity of therapy and to tailor its application to patients’ underlying conditions, especially patients with diabetes.
If you care about diabetes, please read studies about common cholesterol-lowering drugs linked to higher risks of diabetes, skin infections and findings of people with diabetes need to prevent low blood sugar.
For more information about diabetes and your health, please see recent studies about this exercise can help reduce type 2 diabetes risk and results showing that common drugs for inflammation may increase your diabetes risk very fast.
The study is published in Proceedings of the National Academy of Sciences. One author of the study is Katherine Gallagher, M.D.
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