Scientists from the University of Toronto found that even when COVID-19 vaccines fail to prevent hospitalization, they appear to strongly lower the risk of being admitted to intensive care and death compared to patients who are unvaccinated.
The research was presented at the European Congress of Clinical Microbiology & Infectious Diseases and was conducted by Alicia Grima et al.
The rapid development of safe and effective vaccines against the SARS-CoV-2 virus has drastically reduced the burden of COVID-19-related hospitalization and deaths.
However, the risk of breakthrough cases of severe COVID-19 after vaccination remains, particularly among groups at higher risk of severe disease.
In the study, the team examined over 20,000 adults hospitalized in Ontario between January 2021 and January 2022.
The study was restricted to adults with a first COVID-19 infection. The majority of participants (69%) were aged 50 or older, and most were men (54%).
The t4eam found that vaccination with one, two, or three doses strongly reduced the risk of ICU admission and death.
And an inverse dose-response relationship was observed between vaccine doses, with each additional dose reducing the likelihood of ICU admission by 34%, and the odds of dying by 22%.
No big differences in risk were seen regardless of the infecting variant.
The team says even with the diminished efficacy of vaccines against infection with novel variants of concerns, these findings indicate that vaccines remain a vital tool for reducing ICU admission and death from COVID-19.
The good news from this study is that, even when hospitalized with COVID-19, both partial and complete vaccination, reduced the risk of requiring treatment in intensive care and death.
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