How to treat mild to moderate Alzheimer’s disease

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Treating the symptoms of Alzheimer’s can provide people with comfort, dignity, and independence for a longer period of time and can encourage and assist their caregivers as well.

Galantamine, rivastigmine, and donepezil are cholinesterase inhibitors that are prescribed for mild to moderate Alzheimer’s symptoms.

These drugs may help reduce or control some cognitive and behavioral symptoms.

Scientists do not yet fully understand how cholinesterase inhibitors work to treat Alzheimer’s disease, but research indicates that they prevent the breakdown of acetylcholine, a brain chemical believed to be important for memory and thinking.

As Alzheimer’s progresses, the brain produces less and less acetylcholine, so these medicines may eventually lose their effect.

Because cholinesterase inhibitors work in a similar way, switching from one to another may not produce significantly different results, but a person living with Alzheimer’s may respond better to one drug versus another.

Medications that target the underlying causes of a disease are called disease-modifying drugs or therapies. Aducanumab is the only disease-modifying medication currently approved to treat Alzheimer’s.

This medication is a human antibody, or immunotherapy, that targets the protein beta-amyloid and helps to reduce amyloid plaques, which are brain lesions associated with Alzheimer’s.

Clinical studies to determine the effectiveness of aducanumab were conducted only in people with early-stage Alzheimer’s or mild cognitive impairment.

Researchers are continuing to study whether this medication works to affect a person’s rate of cognitive decline over time.

Before prescribing aducanumab, doctors may require PET scans or an analysis of cerebrospinal fluid to evaluate whether amyloid deposits are present in the brain.

This can help doctors make an accurate diagnosis of Alzheimer’s before prescribing the medication.

Once a person is on aducanumab, their doctor or specialist may require routine MRIs to monitor for side effects such as brain swelling or bleeding in the brain.

Several other disease-modifying medications are being tested in people with mild cognitive impairment or early Alzheimer’s as potential treatments.

FDA’s Accelerated Approval Program

Aducanumab was approved through the FDA’s Accelerated Approval Program, which provides a path for earlier approval of drugs that treat certain serious conditions.

This helps people living with the disease gain earlier access to the treatment. The approval of aducanumab was based on the ability of the drug to reduce amyloid in the brain.

When using the accelerated approval pathway, drug companies are required to conduct additional studies to determine whether there is in fact clinical benefit after the drug is approved.

If the follow-up trial fails to verify clinical benefit, the FDA may withdraw approval of the drug. Results of phase 4 clinical trial for aducanumab are expected to be available by early 2030.

If you care about Alzheimer’s disease, please read studies that sleep is the ‘crystal ball’ to predict Alzheimer’s disease, and findings of a new treatment of Alzheimer’s disease.

For more information about brain health, please see recent studies about unhealthy habit may cause Alzheimer’s disease, and results showing this brain disease is the first symptom of COVID-19 for many people.

Source: NIA