In a new study from the Baylor University Medical Center, researchers found a three-day course of remdesivir results in a lower risk for hospitalization or death among patients at high risk for COVID-19 progression.
In the study, the team tested nonhospitalized patients with COVID-19 with symptom onset within the previous seven days and with at least one risk factor for disease progression.
Patients were assigned to receive intravenous remdesivir (200 mg on day 1; 100 mg on days 2 and 3) or placebo (279 and 283 patients, respectively).
The researchers found that two patients in the remdesivir group and 15 in the placebo group had COVID-19-related hospitalization or death.
By day 28, 1.6% and 8.3% of patients in the remdesivir and placebo groups, respectively, had a COVID-19-related medically attended the visit. There were no deaths by day 28.
Adverse events occurred in 42.3% and 46.3% of those in the remdesivir and placebo groups, respectively.
The team says in the campaign toward ending the COVID-19 pandemic, these data add yet another option for the treatment of vulnerable patients who are at high risk of severe COVID-19.
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The study is published in the New England Journal of Medicine. One author of the study is Robert L. Gottlieb, M.D., Ph.D.
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