In a new study from Monash University, researchers found taking a low-dose aspirin once a day does not reduce the risk of thinking and memory problems caused by mild cognitive impairment or probable Alzheimer’s disease, nor does it slow the rate of cognitive decline.
Aspirin has anti-inflammatory properties and also thins the blood. For years, doctors have been prescribing low-dose aspirin for some people to reduce their risk of heart disease and stroke.
However, there are also possible risks to taking aspirin, including bleeding in the brain, so guidance from a doctor is important.
Because aspirin can be beneficial to the heart, researchers have hypothesized, and smaller previous studies have suggested, that it may also be beneficial to the brain, possibly reducing the risk of dementia by reducing inflammation, minimizing small clots or by preventing the narrowing of blood vessels within the brain.
Worldwide, an estimated 50 million people have some form of dementia, a number that is expected to grow as the population increases, so the scientific community is eager to find a low-cost treatment that may reduce a person’s risk.
In the study, the team examined 19,114 people who did not have dementia or heart disease. A majority of participants were age 70 or older. They took thinking and memory tests at the start of the study as well as during follow-up visits.
Half of the people were given daily 100-milligram low-dose aspirin while the other half were given a daily placebo. They were followed for an average of 4.7 years, with annual in-person examinations.
Over the course of the study, 575 people developed dementia.
The team found no difference between those who took aspirin and those who took placebo in the risk of developing mild cognitive impairment, dementia, or probable Alzheimer’s disease.
There was also no difference in the rate of cognitive change over time.
The team says that while these results are disappointing, it is possible that the length of just under five years for the study was not long enough to show possible benefits from aspirin.
A limitation of the study was that only relatively healthy people were enrolled, and such a population may benefit less from aspirin than the general population.
If you care about dementia, please read studies about these commonly prescribed drugs may increase dementia risk and findings of some high blood pressure drugs may prevent dementia, Parkinson’s, Huntington’s.
For more information about dementia and your health, please see recent studies about this common nutrient may protect your brain, preventing dementia and results showing a forgotten symptom of dementia.
The study is published in Neurology. One author of the study is Joanne Ryan, Ph.D.
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