In a new study, researchers found with the help of a new optical imaging technique, cervical cancer can be detected with a hand-held microscope.
They found targeting the PARP1 enzyme that is over-expressed in cervical cancer can have the potential to revolutionize cervical cancer screening.
Most cases of cervical cancer are caused by the human papilloma virus (HPV), which can live in a woman’s body for years before turning cervical cells cancerous.
Despite the HPV vaccination and efforts in disease prevention with screening programs, cervical cancer still has a high incidence across the globe.
It remains a big problem in public health, especially in low-resource areas where HPV incidence is typically high.
In the study, the team found this clinical problem could be circumvented by a simple, in vivo, non-invasive, cost-effective, point-of-care method of diagnosis.
They used the topically applied targeted tracer, PARPi-FL.
The study included cervical biopsies from animal models and humans in which the expression of the PARP1 enzyme was assessed.
Researchers analyzed the expression of PARP1 in cervical cells, and histological exams were performed to verify the presence of the enzyme.
When imaging biopsies that contained tumors, PARPi-FL showed higher uptake in lesions compared to surrounding normal tissue, which corresponded to PARP1 expression in those areas.
The tumors cells also showed a disorganized pattern and heterogeneously shaped nuclei, which was easily discernible using PARPi-FL.
The team says assessing lesions using this imaging-based approach is non-invasive, safe, painless, and may be used to accurately diagnose and manage the treatment of several cancers, including cervical cancer.
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The study is published in The Journal of Nuclear Medicine. One author of the study is Elizabeth Jewell, MD, MHSc, FACOG, FACS.
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