In a new review study from Curtin University, researchers found that chronic psychosocial stress—which involves a pathway called the hypothalamic-pituitary-adrenal axis (HPA axis)—may contribute to the development of Alzheimer’s disease.
They reported how environmental and genetic factors can impact individuals’ HPA axis, and ultimately their risk of Alzheimer’s disease.
The review also proposes a mechanism by which genetic factors that influence the HPA axis may also affect inflammation, a key driver of neurodegeneration.
The team says that chronic stress does affect many biological pathways within our body.
There is an intimate interplay between exposure to chronic stress and pathways influencing the body’s reaction to such stress.
Genetic variations within these pathways can influence the way the brain’s immune system behaves leading to a dysfunctional response.
In the brain, this leads to chronic disruption of normal brain processes, increasing the risk of subsequent neurodegeneration and ultimately dementia.
If you care about Alzheimer’s disease, please read studies about a new way to accurately detect Alzheimer’s disease and findings of this stuff in the brain may protect you from Alzheimer’s disease.
For more information about Alzheimer’s disease and your health, please see recent studies about this food nutrient may help lower risk of Alzheimer’s, dementia and results showing that this new drug may treat cancer, Alzheimer’s, heart disease, and more.
The study is published in Biological Reviews. One author of the study is David Groth, Ph.D..
Copyright © 2021 Knowridge Science Report. All rights reserved.
