In a new study from the Chinese People’s Liberation Army General Hospital, researchers found how common hospitalized patients develop liver injury from taking different medications.
The team analyzed the records of 156,570 hospitalized patients, and they found 499 cases of drug-induced liver injury, for an incidence of 0.32%.
Anti-infective drugs, cancer medications, and non-steroidal anti-inflammatory drugs were the major categories of drugs causing liver injury, and the highest incidence was due to voriconazole (an antifungal medication).
Patients with high cholesterol, cardiovascular disease, pre-existing liver disease, and prior surgeries faced a higher risk of drug-induced liver injury.
The team says they carried out a drug-induced liver injury-related real-world study with the help of information technology to provide a more accurate reference for safe and rational drug use.
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The study is published in the British Journal of Clinical Pharmacology. One author of the study is DaiHong Guo.
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