In a new study from the University of Ljubljana, researchers found that testosterone therapy may reduce non-alcoholic fatty liver disease in obese men with type-2 diabetes.
They found that therapy with testosterone undecanoate normalized testosterone levels, reduced NAFLD, and suppressed the symptoms in men living with these conditions.
NAFLD is emerging as a public health issue worldwide. It is estimated that prevalent cases will increase 21% by 2030, from 83.1 million to 100.9 million.
NAFLD is more commonly found in people with type-2 diabetes and is linked to obesity and insulin resistance. It refers to excess fat accumulation in the liver, in the absence of excessive alcohol consumption.
Alcohol consumption of less than 30 g (3.75 units) per day for men is used as the cut-off to diagnose NAFLD.
In the study, the team examined the effects of testosterone therapy on blood sugar control, metabolic functions, vascular function in obese men with type-2 diabetes.
They tested 55 males with type-2 diabetes.
During the study, the participants were divided into two groups. The first group received testosterone undecanoate during both years of the study, while the second group received a placebo in the first year and testosterone therapy in the second year.
The team found that therapy with testosterone undecanoate normalized testosterone levels, reduced NAFLD, and suppressed the symptoms.
They say that the improvement of NAFLD as a result of improved insulin resistance, reduction in body mass index and body weight, along with changes in body composition.
Testosterone increases lean body mass at the expense of fat mass, either alone or in combination with behavioral and lifestyle modifications.
Testosterone with its anti-inflammatory effects also reduced the chronic inflammatory state in the liver.
This study shows that testosterone therapy could be used as a suitable therapy for obese men living with non-alcoholic fatty liver disease, and therefore the findings can be used to tackle this growing pandemic.
If you care about liver health, please read studies about the cause of fatty liver disease and findings of this diet may reduce non-alcoholic fatty liver disease by 50%.
For more information about liver disease prevention and treatment, please see recent studies about this diet may help prevent drug induced liver damage and results showing that common acid reflux drugs linked to chronic liver disease.
The study was presented at the 23rd European Congress of Endocrinology. One author of the study is Dr. Kristina Groti Antonic.
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