There are several million people worldwide with various fat malabsorption syndromes including those who have undergone gastric bypass surgery and those with obesity.
These patients often have a difficult time absorbing vitamin D and both groups of patients are at an increased risk for vitamin D deficiency and therefore at higher risk for osteoporosis and osteomalacia (softening of the bones).
Patients with obesity are also susceptible to vitamin D deficiency as vitamin D derived from intestinal absorption and cutaneous synthesis is diluted in a larger body pool of fat.
In a new study from Boston University, researchers found that 25-hydroxyvitamin D3 is an effective treatment for vitamin D deficiency for these specific patients.
According to them, approximately one-third of adults are obese and require much larger doses of vitamin D to satisfy their requirements.
This vitamin D metabolite is better absorbed in patients with fat malabsorption syndromes and since it is not as fat-soluble, it does not gets diluted in the body fat and is effective in raising and maintaining blood levels of 25-hydroxyvitamin D in obese people.
In the study, the team found that compared to healthy adults, only about 36% of orally ingested vitamin D3 was found in the blood of patients with fat malabsorption syndromes including patients who had gastric bypass surgery.
When the same adults ingested 25-hydroxyvitamin D3, the patients with fat malabsorption syndromes were able to absorb it as well as the healthy adults thereby raising their vitamin D status to the same degree.
The team says using 25-hydroxyvitamin D3 could be a novel approach for treating vitamin D deficiency in patients with fat malabsorption syndromes and obese adults.
Vitamin D deficiency not only results in bone loss increasing risk for fracture but causes the painful bone disease osteomalacia.
Patients who are vitamin D deficient with osteomalacia have unrelenting achiness in their bones and muscles.
Vitamin D deficiency has been associated with an increased risk of many chronic illnesses including multiple sclerosis, type 1 diabetes, heart disease, type 2 diabetes, depression, neurocognitive dysfunction and Alzheimer’s disease as well as infectious diseases including COVID.
If you care about vitamins and your health, please read studies about healthy vitamin D level in the body can help prevent cancer and findings of this vitamin may help treat vision loss.
For more information about vitamins and wellness, please see recent studies about this vitamin may help battle deadly brain tumor and results showing that vitamin D could be an effective way to fight against diabetes.
The study is published in the American Journal of Clinical Nutrition. One author of the study is Michael F. Holick, Ph.D., MD.
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