Lack of this vitamin may lead to dementia, study finds

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In a recent study published in Alzheimer’s and Dementia, researchers suggest that iron deposits in the brain—resulting from alcohol-induced vitamin B1 deficiency—can be regarded as key factors in cognitive decline.

They explained alcohol-induced brain damage: Cognitive deterioration is caused by iron deposits in the brain, but the administration of vitamin B1 could protect the brain from these deposits.

The study is from MedUni Vienna. One author is Stephan Listabarth.

A common consequence of chronically high alcohol drinking is a decline in cognitive function, which can even progress to full-blown dementia.

This is then referred to as alcohol-related dementia. However, researchers do not yet fully understand the exact mechanism by which the brain is damaged by alcohol.

Previous research had shown that iron deposits in the brain are responsible for nerve tissue damage.

These deposits can also be detected in specific regions of the brain (including the basal ganglia) in people who drink a lot of alcohol.

In the current paper, the team says high alcohol consumption results in elevated iron levels in the blood and vitamin B1 (thiamine) deficiency, which, among other things, is important for maintaining the blood-brain barrier.

If these two situations coincide, more iron will be deposited inside the brain, ultimately leading to oxidative tissue damage.

This newly described role of vitamin B1 in this process could represent a huge step forward in the understanding of the development of alcohol-related neurological damage.

It also can offer a new point of attack for preventive and therapeutic approaches.

It would then be conceivable to give continuous vitamin B1 substitution in the future as a preventive measure.

The researchers believe it would also be useful to evaluate the use of drugs to reduce iron levels (e.g. chelators), as is already done in other neurodegenerative diseases.

The team has already started planning a prospective clinical study to validate the above-mentioned relationship between alcohol dependency, vitamin B1 deficiency, and cerebral iron deposits and to provide a basis for further research in the field of alcohol-related dementia in the future.

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