In a recent study at Laval University in Canada, researchers found it might be possible to reduce the chances of developing Alzheimer’s disease by editing a key gene in nerve cells.
The study is published in bioRxiv. One author is Antoine Guyon.
Previous research has found that one factor involved in the development of Alzheimer’s disease is a buildup of beta-amyloid—a type of protein—on brain cells.
It has also shown that some people have a gene variant called A673T—those who express it are four times less likely than the general populace to develop Alzheimer’s disease.
In this study, the team looked into the possibility of editing human brain cells to give people the gene variant A673T and thereby reduce their chances of developing Alzheimer’s disease.
They found that the A673T mutation differs from its cognate in those who do not express it by a single DNA letter, suggesting it might be relatively easy to add the mutation.
They next tried editing brain cells using a CRISPR technique.
And while that attempt proved relatively successful, other aspects of the technique drove the researchers to try another—prime editing.
This relatively new technique allows for directly converting one base letter to another.
Using this technique, the researchers found that they were able to edit approximately 40% of the brain cells in vitro.
They note that such an amount is likely not high enough to prevent the buildup of beta-amyloid, and thus not enough to slow the onset of Alzheimer’s disease. But more research might lead to better results.
The team also says that such editing of brain cells in humans would require early diagnosis because, by the time symptoms present, it might be too late to conduct gene editing to prevent the buildup of beta-amyloid.
They suggest that future efforts might instead involve editing the DNA of only those who are deemed at risk of developing the disease while they are still young.
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