In a new study, researchers examined more than a half-million people in India who were exposed to the novel coronavirus SARS-CoV-2, or COVID-19.
They found that the virus’s continued spread is driven by only a small percentage of those who become infected.
Furthermore, children and young adults were found to be potentially much more important to transmit the virus—especially within households—than previous studies have identified.
The research was conducted by a team from Princeton University and elsewhere.
In the study, the team tracked the infection pathways and death rate of 575,071 people in India who were exposed to 84,965 confirmed cases of SARS-CoV-2.
It is the largest contact-tracing study—which is the process of identifying people who came into contact with an infected person—conducted in the world for any disease.
The study is the first large study to capture the extraordinary extent to which COVID-19 hinges on “superspreading,” in which a small percentage of the infected population passes the virus on to more people.
The researchers found that 71% of infected individuals did not infect any of their contacts, while a mere 8% of infected individuals accounted for 60% of new infections.
The findings provide extensive insight into the spread and deadliness of COVID-19 in countries such as India—which has experienced more than 96,000 deaths from COVID-19—that have a high incidence of resource-limited populations.
They found that coronavirus-related deaths in India occurred, on average, six days after hospitalization compared to an average of 13 days in the United States.
Also, deaths from coronavirus in India have been concentrated among people aged 50-64, which is slightly younger than the 60-plus at-risk population in the United States.
The researchers also reported, however, the first large-scale evidence that the implementation of a country-wide shutdown in India led to substantial reductions in coronavirus transmission.
They found that the chances of a person with coronavirus, regardless of their age, passing it on to a close contact ranged from 2.6% in the community to 9% in the household.
They also found that children and young adults—who made up one-third of COVID cases—were especially key to transmitting the virus in resource-limited populations.
The team says kids are very efficient transmitters in this setting, which is something that hasn’t been firmly established in previous studies.
They found that reported cases and deaths have been more concentrated in younger cohorts than they expected based on observations in higher-income countries.
Children and young adults were much more likely to contract coronavirus from patients their own age, the study found.
In general, same-age contacts across all age groups greatly increased the chance of infection, with the probability of catching coronavirus from low- to high-risk contacts ranging from 4.7-10.7%, respectively.
One author of the study is Ramanan Laxminarayan, a senior research scholar.
The study is published in Science.
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