In a new study, researchers found a single dose of cannabidiol (CBD) helped increase blood flow to the hippocampus, an important area of the brain associated with memory and emotion.
The findings could be an important discovery for conditions that affect memory, such as Alzheimer’s disease and post-traumatic stress disorder (PTSD), and could help better target therapies.
The research was conducted by a team at UCL and elsewhere.
Cannabidiol is one of the main constituents of cannabis and is gaining interest for its therapeutic potential.
There is evidence that CBD may help reduce symptoms of psychosis and anxiety. There is some evidence to suggest that CBD may improve memory function.
Additionally, CBD changes how the brain processes emotional memories, which could help to explain its reputed therapeutic effects in PTSD and other psychiatric disorders.
However, the precise mechanisms underlying the effects of CBD on memory are unclear.
In the study, the team set out to test how CBD influences cerebral blood flow in different regions on the brain involved in memory processing.
They tested 15 healthy young adult participants, with little or no history of cannabis use.
On different occasions, separated by at least a week, each participant was given 600 mg of oral CBD or a placebo.
The doses came in identical capsules, so participants didn’t know which one they were taking on which occasion.
The researchers measured blood flow to the hippocampus using ‘arterial spin labeling’ – a magnetic resonance imaging (MRI) brain scanning technique which measures changes in the blood oxygen levels.
They found CBD strongly increased blood flow in the hippocampus, however, CBD did not cause big differences in blood flow in other regions of the medial temporal lobe (MTL), of which the hippocampus is a significant component.
In the prefrontal cortex, the area of the brain used for planning and decision making, CBD caused a big increase in blood flow in the orbitofrontal cortex.
This is the first study to find that CBD increases blood flow to key regions involved in memory processing, particularly the hippocampus.
This supports the view that CBD has region-specific blood flow effects in the human brain, which has previously been disputed.
If replicated, these results could lead to further research across a range of conditions characterized by changes in how the brain processes memories, including Alzheimer’s disease, where there are defects in the control of blood control flow, along with schizophrenia and PTSD.
This study used a single dose of CBD in healthy volunteers, which may not translate to the effects of repeated CBD dosing.
One author of the study is Dr. Michael Bloomfield (UCL Psychiatry).
The study is published in the Journal of Psychopharmacology.
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