This number may predict coronary artery disease effectively

Because coronary artery disease (CAD) remains the leading cause of death worldwide, there is tremendous attention given to its risk factors.

Estrogen protects women’s cardiovascular systems before menopause, which helps explain why the incidence of CAD in premenopausal women is lower than in men.

However, as women’s estrogen levels decline during and after menopause, the incidence of CAD in postmenopausal women outpaces similarly aged men.

In a recent study, researchers found the location of the fat that matters most for heart health.

They found belly fat (waist size) representing the greatest harm and not overall body mass index (BMI) when assessing risk for CAD.

The study is published in Menopause. One author is Dr. Stephanie Faubion, NAMS medical director.

Obesity has long been known as a risk factor for CAD because it causes endothelial cell dysfunction, insulin resistance, and coronary atherosclerosis, among other problems.

It also is often accompanied by other risk factors, such as high blood pressure and diabetes.

In the past, it has been suggested that overall obesity (which is often defined by BMI) is a primary risk factor.

Few studies have attempted to compare the effect of overall obesity versus central obesity, which is typically described by waist circumference and/or waist-to-hip ratio.

In this study, the team examined nearly 700 Korean women and demonstrated that the presence of CAD was much higher in women with a bigger waistline.

No strong difference was identified based on BMI, indicating that overall obesity was not a risk factor for obstructive CAD.

These results are especially relevant for postmenopausal women because menopause causes a change in body fat distribution, especially in the abdominal area.

The team says identifying women with excess abdominal fat, even with a normal BMI, is important so that lifestyle interventions can be implemented.

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