The development of the late-onset form of Alzheimer’s disease is affected by genetic and environmental factors, including lifestyle.
Environmental factors can alter the function of the genes associated with the disease by modifying their epigenetic regulation, e.g. by influencing the bond formation of methyl groups in the DNA’s regulatory regions which control function of the genes.
In a recent study from the University of Turku, researchers have discovered changes in blood samples linked to Alzheimer’s disease.
They examined disease-discordant twin pairs: one sibling who suffered from Alzheimer’s disease and one who was cognitively healthy.
They used the latest genome-wide methods to find out whether the twins’ blood samples had any disease-related differences in epigenetic marks, which are sensitive to changes in environmental and lifestyle factors.
Differences in epigenetic marks between the sibling who suffered from Alzheimer’s disease and the healthy sibling were discovered in multiple genomic regions.
The study is published in Clinical Epigenetics.
By measuring methylation levels in the DNA isolated from the Finnish twins’ blood samples, the team discovered epigenetic marks associated with Alzheimer’s disease in multiple genomic regions.
One of the marks appeared stronger in the brain samples of the patients suffering from Alzheimer’s disease.
The link between this mark and Alzheimer’s disease was confirmed in the Swedish twin cohorts.
The researchers observed that the strength of the mark was influenced not only by the disease, but also age, gender and APOE genotype, which is known to associate with the risk of developing Alzheimer’s disease.
Furthermore, the mark was stronger in those twins with Alzheimer’s disease who had been smoking.
The function of the gene where the mark is located is still not well understood. The gene product is suspected to inhibit the activity of certain brain enzymes that edit the code translated from DNA to direct the formation of proteins.
Previous research had shown that removing this genomic region caused learning and memory problems which are central symptoms of Alzheimer’s disease.
The team says that even though the results offer new information about the molecular mechanisms of Alzheimer’s disease, more research is needed on whether the discovered epigenetic marks could be utilized in diagnostics.
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