In a new study, researchers found a compound in hops may help thwart liver and colon cancer cells.
Hops are a plant that adds flavor, color, and bitterness to beer. The compound is called xanthohumol, known as XN.
The team also found that two important derivatives of the compound may help fight cancer cells too.
The findings may help develop new cancer treatments in the future.
The research was conducted by a team from Oregon State University.
Colorectal cancer is the third most common cause of cancer-related death in the United States, and liver cancer ranks fifth.
The incidence of liver cancer, though, has tripled in the last four decades.
In the study, the team found that the compound XN is produced by Humulus lupulus, the common hop plant.
Previous research has shown that XN inhibits cell growth in a variety of cancer cell lines.
In this study, the team showed that XN’s ability to halt cell growth and kill two liver cancer cell lines and two colon cancer cell lines.
They tested liver and colon cancer cell lines because the oral consumption of XN and its derivatives can lead to high concentrations in the gut and liver.
The team also found the two derivatives from the compound have cancer-fighting effectiveness similar to that of XN in liver and colon cancer cells.
The derivatives also help fight metabolic syndrome, reducing weight gain.
The team says that for both liver and colon cancer, discovering new compounds for prevention and treatment is very important.
Their findings show that the hop compound XN and its derivatives DXN and TXN can inhibit cell growth and caused cell death.
The results may help develop new treatments for diseases in the future.
The lead author of the study is Adrian Gombart, professor of biochemistry and biophysics in the College of Science at Oregon State University.
The study is published in the International Journal of Molecular Sciences.
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