In a new study, researchers found that two hormones may help burn fat faster and prevent diabetes.
They two hormones called “notum” and “lipocalin-5” could speed up the body’s ability to burn fat.
The research was conducted by UCLA geneticists.
In the study, the researchers developed a new technique to hunt for hormones that influence how organs and tissues communicate with each other.
The new method helped them find naturally occurring molecules that play major roles in type 2 diabetes, obesity, and cardiovascular disease.
Lipocalin-5 is a hormone that can protect animals from developing diabetes or cure the disease after they develop it.
The hormone also enhanced muscle tissue’s ability to metabolize and absorb dietary nutrients, reducing the risk of obesity and diabetes.
The researchers identified and studied the hormonal networks in mice.
After that, they tested whether the functions they assigned to the hormones remained consistent in humans.
The team found a strong overlap between these hormones’ functions in mice and humans.
They focused on how hormonal functions change in people with diabetes and cardiovascular disease and were able to find new ways that tissues signal each other and restore normal communication.
The researchers suggest the new findings could deepen understanding of obesity and common risk factors for heart disease and diabetes.
The team will also apply the new method to evaluate tissue-to-tissue communication across different ethnicities and diseases.
Future studies will examine how the newly identified hormones in humans communicate between unrelated types of tissue.
They hope to use these hormones as the basis for drug development, specifically for treating obesity and Type 2 diabetes.
The study is published in Cell Metabolism.
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